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240501s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202402434
|2 doi
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|a pubmed24n1468.xml
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|a (DE-627)NLM371730155
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|a (NLM)38684233
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|a DE-627
|b ger
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|e rakwb
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|a eng
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|a Xu, Ruohan
|e verfasserin
|4 aut
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|a Less is More
|b Asymmetric D-A Type Agent to Achieve Dynamic Self-Assembled Nanoaggregates for Long-Acting Photodynamic Therapy
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.07.2024
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|a Date Revised 12.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a To enhance the phototheranostic performance, agents with high reactive oxygen species (ROS) generation, good tumor-targeting ability, and prolonged retention are urgently needed. However, symmetric donor-acceptor (D-A) type agents usually produce spherical nanoaggregates, leading to good tumor targeting but inferior retention. Rod-like nanoaggregates are desired to extend their retention in tumors; however, this remains a challenge. In particular, agents with dynamically changeable shapes that integrate merits of different morphologies are seldomly reported. Therefore, self-assembled organic nanoaggregates with smart shape tunability are designed here using an asymmetric D-A type TIBT. The photoluminescence quantum yield in solids is up to 52.24% for TIBT. TIBT also exhibits high ROS generation in corresponding nanoaggregates (TIBT-NCs). Moreover, dynamic self-assembly in shape changing from nanospheres to nanorods occurrs in TIBT-NCs, contributing to the enhancement of ROS quantum yield from 0.55 to 0.72. In addition, dynamic self-assembly can be observed for both in vitro and in vivo, conferring TIBT-NCs with strong tumor targeting and prolonged retention. Finally, efficient photodynamic therapy to inhibit tumor growth is achieved in TIBT-NCs, with an inhibition rate of 90%. This work demonstrates that asymmetric D-A type agents can play significant roles in forming self-assembled organic nanoaggregates, thus showing great potential in long-acting cancer therapy
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|a Journal Article
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|a D–A architecture
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|a aggregation‐induced emission
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|a organic nanoaggregate
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|a photodynamic therapy
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|a self‐assembly
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Shen, Qifei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Peijuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zhi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Yanzi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meng, Lingjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dang, Dongfeng
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 28 vom: 02. Juli, Seite e2402434
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:28
|g day:02
|g month:07
|g pages:e2402434
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|u http://dx.doi.org/10.1002/adma.202402434
|3 Volltext
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