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240426s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202402182
|2 doi
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|a pubmed24n1468.xml
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|a (NLM)38663035
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Yang, Xueqin
|e verfasserin
|4 aut
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|a Donor-Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR-II Emission
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 12.07.2024
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|a Date Revised 12.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Photosensitizers (PSs) with aggregation-induced emission (AIE) characteristics are competitive candidates for bioimaging and therapeutic applications. However, their short emission wavelength and nonspecific organelle targeting hinder their therapeutic effectiveness. Herein, a donor-acceptor modulation approach is reported to construct a series of ionic AIE photosensitizers with enhanced photodynamic therapy (PDT) outcomes and fluorescent emission in the second near-infrared (NIR-II) window. By employing dithieno[3,2-b:2',3'-d]pyrrole (DTP) and indolium (In) as the strong donor and acceptor, respectively, the compound DTP-In exhibits a substantial redshift in absorption and fluorescent emission reach to NIR-II region. The reduced energy gap between singlet and triplet states in DTP-In also increases the reactive oxygen species (ROS) generation rate. Further, DTP-In can self-assemble in aqueous solutions, forming positively charged nanoaggregates, which are superior to conventional encapsulated nanoparticles in cellular uptake and mitochondrial targeting. Consequently, DTP-In aggregates show efficient photodynamic ablation of 4T1 cancer cells and outstanding tumor theranostic in vivo under 660 nm laser irradiation. This work highlights the potential of molecular engineering of donor-acceptor AIE PSs with multiple functionalities, thereby facilitating the development of more effective strategies for cancer therapy
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|a Journal Article
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|a aggregation‐induced emission
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|a donor–acceptor modulating
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|a mitochondria‐targeting
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|a near‐infrared emission
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|a photodynamic therapy
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|a Photosensitizing Agents
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Indoles
|2 NLM
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|a Pyrroles
|2 NLM
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| 700 |
1 |
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|a Wang, Xinyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jianyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lam, Jacky W Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Haitao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Jinglei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Yongye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Ben Zhong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 28 vom: 12. Juli, Seite e2402182
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:28
|g day:12
|g month:07
|g pages:e2402182
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|u http://dx.doi.org/10.1002/adma.202402182
|3 Volltext
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