Segmental duplications drive the evolution of accessory regions in a major crop pathogen

Segmental duplications drive the evolution of accessory regions in a major crop pathogen

© 2024 The Authors New Phytologist © 2024 New Phytologist Foundation.

Détails bibliographiques
Publié dans:The New phytologist. - 1979. - 242(2024), 2 vom: 07. Apr., Seite 610-625
Auteur principal: van Westerhoven, Anouk C (Auteur)
Autres auteurs: Aguilera-Galvez, Carolina, Nakasato-Tagami, Giuliana, Shi-Kunne, Xiaoqian, Martinez de la Parte, Einar, Chavarro-Carrero, Edgar, Meijer, Harold J G, Feurtey, Alice, Maryani, Nani, Ordóñez, Nadia, Schneiders, Harrie, Nijbroek, Koen, Wittenberg, Alexander H J, Hofstede, Rene, García-Bastidas, Fernando, Sørensen, Anker, Swennen, Ronny, Drenth, Andre, Stukenbrock, Eva H, Kema, Gert H J, Seidl, Michael F
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:The New phytologist
Sujets:Journal Article Fusarium oxysporum accessory regions genome compartmentalization pathogen genome evolution segmental duplications
Description
Résumé:© 2024 The Authors New Phytologist © 2024 New Phytologist Foundation.
Many pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum has such ARs, often spanning entire chromosomes. The presence of specific ARs influences the host range, and horizontal transfer of ARs can modify the pathogenicity of the receiving strain. However, how these ARs evolve in strains that infect the same host remains largely unknown. We defined the pan-genome of 69 diverse F. oxysporum strains that cause Fusarium wilt of banana, a significant constraint to global banana production, and analyzed the diversity and evolution of the ARs. Accessory regions in F. oxysporum strains infecting the same banana cultivar are highly diverse, and we could not identify any shared genomic regions and in planta-induced effectors. We demonstrate that segmental duplications drive the evolution of ARs. Furthermore, we show that recent segmental duplications specifically in accessory chromosomes cause the expansion of ARs in F. oxysporum. Taken together, we conclude that extensive recent duplications drive the evolution of ARs in F. oxysporum, which contribute to the evolution of virulence
Description:Date Completed 22.03.2024
Date Revised 22.03.2024
published: Print-Electronic
RefSeq: GCF_000149955.1, GCF_000240135.3, GCF_000149555.1, GCF_020744495.1
Citation Status MEDLINE
ISSN:1469-8137
DOI:10.1111/nph.19604