|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM368434729 |
| 003 |
DE-627 |
| 005 |
20240603233156.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
240214s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202313029
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1427.xml
|
| 035 |
|
|
|a (DE-627)NLM368434729
|
| 035 |
|
|
|a (NLM)38353366
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Guo, Xun
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Decomposable Nanoagonists Enable NIR-Elicited cGAS-STING Activation for Tandem-Amplified Photodynamic-Metalloimmunotherapy
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 24.05.2024
|
| 500 |
|
|
|a Date Revised 03.06.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2024 Wiley‐VCH GmbH.
|
| 520 |
|
|
|a Activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has emerged as an efficient strategy to improve the therapeutic outcomes of immunotherapy. However, the "constantly active" mode of current STING agonist delivery strategies typically leads to off-target toxicity and hyperimmunity. To address this critical issue, herein a metal-organic frameworks-based nanoagonist (DZA7) featuring tumor-specific and near-infrared (NIR) light-enhanced decomposition is constructed for precisely localized STING activation and photodynamic-metalloimmunotherapy. The engineered nanoagonist enabled the generation of mitochondria-targeted reactive oxygen species under NIR irradiation to specifically release mitochondrial DNA (mtDNA) and inhibit the repair of nuclear DNA via hypoxia-responsive drugs. Oxidized tumor mtDNA serves as an endogenous danger-associated molecular pattern that activates the cGAS-STING pathway. Concurrently, NIR-accelerated zinc ions overloading in cancer cells further enhance the cGAS enzymatic activity through metalloimmune effects. By combining the synergistically enhanced activation of the cGAS-STING pathway triggered by NIR irradiation, the engineered nanoagonist facilitated the maturation of dendritic cells and infiltration of cytotoxic T lymphocytes for primary tumor eradication, which also established a long-term anti-tumor immunity to suppress tumor metastasis. Therefore, the developed nanoagonist enabled NIR-triggered, agonist-free, and tandem-amplified activation of the cGAS-STING pathway, thereby offering a distinct paradigm for photodynamic-metalloimmunotherapy
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a cancer immunotherapy
|
| 650 |
|
4 |
|a cyclic GMP‐AMP synthase‐stimulator of interferon genes pathway
|
| 650 |
|
4 |
|a metalloimmunotherapy
|
| 650 |
|
4 |
|a nanoagonists
|
| 650 |
|
4 |
|a photodynamic therapy
|
| 650 |
|
7 |
|a Membrane Proteins
|2 NLM
|
| 650 |
|
7 |
|a Nucleotidyltransferases
|2 NLM
|
| 650 |
|
7 |
|a EC 2.7.7.-
|2 NLM
|
| 650 |
|
7 |
|a Metal-Organic Frameworks
|2 NLM
|
| 650 |
|
7 |
|a Reactive Oxygen Species
|2 NLM
|
| 650 |
|
7 |
|a DNA, Mitochondrial
|2 NLM
|
| 650 |
|
7 |
|a STING1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a cGAS protein, human
|2 NLM
|
| 650 |
|
7 |
|a EC 2.7.7.-
|2 NLM
|
| 650 |
|
7 |
|a Photosensitizing Agents
|2 NLM
|
| 700 |
1 |
|
|a Tu, Peng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Xiaoting
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Du, Chier
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jiang, Weixi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Qiu, Xiaoling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Jingxue
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Liang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Yu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ren, Jianli
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 21 vom: 01. Mai, Seite e2313029
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:36
|g year:2024
|g number:21
|g day:01
|g month:05
|g pages:e2313029
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202313029
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 36
|j 2024
|e 21
|b 01
|c 05
|h e2313029
|