Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density

Transferrin-conjugated polymersomes, transferrin-biotin/avidin/biotin-Pluronic F127-poly(lactic acid) (Tf-F127-PLA), were successfully prepared through a biotin-avidin bridging technique to study their ability to inhibit multidrug resistance of cancer cells. Hydrophilic doxorubicin (DOX) was selecte...

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Publié dans:Langmuir : the ACS journal of surfaces and colloids. - 1985. - 39(2023), 45 vom: 14. Nov., Seite 15920-15931
Auteur principal: Yi, Shui Ling (Auteur)
Autres auteurs: Li, Zi Ling, Gong, Yan Chun, Xiong, Xiang Yuan
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Langmuir : the ACS journal of surfaces and colloids
Sujets:Journal Article Research Support, Non-U.S. Gov't Avidin 1405-69-2 Biotin 6SO6U10H04 Doxorubicin 80168379AG Ligands Polyesters plus... Transferrin UCON 50-HB-5100 9038-95-3