Insight on the Intracellular Supramolecular Assembly of DTTO A Peculiar Example of Cell-Driven Polymorphism

Insight on the Intracellular Supramolecular Assembly of DTTO : A Peculiar Example of Cell-Driven Polymorphism

© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 42 vom: 12. Okt., Seite e2302756
1. Verfasser: Aloisio, Ludovico (VerfasserIn)
Weitere Verfasser: Moschetta, Matteo, Boschi, Alex, Fleitas, Ariel García, Zangoli, Mattia, Venturino, Ilaria, Vurro, Vito, Magni, Arianna, Mazzaro, Raffaello, Morandi, Vittorio, Candini, Andrea, D'Andrea, Cosimo, Paternò, Giuseppe Maria, Gazzano, Massimo, Lanzani, Guglielmo, Di Maria, Francesca
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article biomaterials electroactive fibers polymorphs supramolecular assembly thiophene Biocompatible Materials
Beschreibung
Zusammenfassung:© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
The assembly of supramolecular structures within living systems is an innovative approach for introducing artificial constructs and developing biomaterials capable of influencing and/or regulating the biological responses of living organisms. By integrating chemical, photophysical, morphological, and structural characterizations, it is shown that the cell-driven assembly of 2,6-diphenyl-3,5-dimethyl-dithieno[3,2-b:2',3'-d]thiophene-4,4-dioxide (DTTO) molecules into fibers results in the formation of a "biologically assisted" polymorphic form, hence the term bio-polymorph. Indeed, X-ray diffraction reveals that cell-grown DTTO fibers present a unique molecular packing leading to specific morphological, optical, and electrical properties. Monitoring the process of fiber formation in cells with time-resolved photoluminescence, it is established that cellular machinery is necessary for fiber production and a non-classical nucleation mechanism for their growth is postulated. These biomaterials may have disruptive applications in the stimulation and sense of living cells, but more crucially, the study of their genesis and properties broadens the understanding of life beyond the native components of cells
Beschreibung:Date Completed 23.10.2023
Date Revised 23.10.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202302756