Multimodal Imaging Study of Patients With Vitamin A Deficiency Retinopathy

Multimodal Imaging Study of Patients With Vitamin A Deficiency Retinopathy

OBJECTIVES: To describe multimodal imaging findings of vitamin A deficiency retinopathy

Bibliographische Detailangaben
Veröffentlicht in:Ophthalmic surgery, lasers & imaging retina. - 2013. - 54(2023), 6 vom: 23. Juni, Seite 330-336
1. Verfasser: Pichi, Francesco (VerfasserIn)
Weitere Verfasser: Aljneibi, Shaikha, Neri, Piergiorgio, Rishi, Pukhraj, Cicinelli, Maria Vittoria, Introini, Ugo, Sharma, Sumit, Munk, Marion R, Pasadhika, Sirichai, Gonzalez-Lopez, Julio J, Lembo, Andrea, Nucci, Paolo, Choudhry, Netan, Carreño, Ester
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Ophthalmic surgery, lasers & imaging retina
Schlagworte:Journal Article
Beschreibung
Zusammenfassung:OBJECTIVES: To describe multimodal imaging findings of vitamin A deficiency retinopathy
METHODS: A retrospective study of patients with serum retinol < 0.3 mg/L. Fundus color photos, spectral domain-optical coherence tomography (SD-OCT), and fundus autofluorescence (FAF) were reviewed and, when available, electrophysiological tests were analyzed
RESULTS: Forty-five eyes (63.9 ± 15.7 years) were included. Ultra-widefield fundus photography showed drusen-like deposits (53.3%) and macular retinal pigment epithelium (RPE) mottling (40%). The deposits were hypoautofluorescent, and a perifoveal hyperautofluorescent ring was present in 8.9%. By SD-OCT, the ellipsoid zone had an irregular appearance (100%) and conical deposits anterior to the RPE (33.3%). Electroretinogram (ERG) (66.7%) showed a decrease in b-wave in the scotopic registers, and microperimetry (4.4%) showed decreased foveal sensitivity. After vitamin A supplementation, SD-OCT and FAF showed resolution of all findings. Forty percent of eyes had restoration of the scotopic registers in ERG and improved macular sensitivity by microperimetry (4.4%)
CONCLUSIONS: Vitamin A deficiency causes a mild cone dysfunction in addition to the more severe absent rod response. [Ophthalmic Surg Lasers Imaging Retina 2023;54:330-336.]
Beschreibung:Date Completed 26.06.2023
Date Revised 16.11.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:2325-8179
DOI:10.3928/23258160-20230513-01