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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202303186
|2 doi
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|a pubmed24n1193.xml
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|a (DE-627)NLM358139015
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|a (NLM)37312246
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhang, Tianfu
|e verfasserin
|4 aut
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|a Tailoring the Amphiphilic Structure of Zwitterionic AIE Photosensitizers to Boost Antitumor Immunity
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.09.2023
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|a Date Revised 22.09.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Although photodynamic therapy (PDT) for thorough cancer treatment is hindered by the limited generation of reactive oxygen species (ROS) with short lifetime from photosensitizers, PDT-induced antitumor immune response remedies the defects. Previous studies show that inducing immunogenic cell deaths is an attractive approach to activate antitumor immunity, which confers a robust adjuvanticity to dying cancer cells. In this work, amphiphilic luminogens with aggregation-induced emission characteristics (AIEgens) are rationally designed and synthesized. By modulating the hydrophobic π-bridge and zwitterionic functional groups, these AIEgens exhibit tunable organelle specificity to lysosome, endoplasmic reticulum, and plasma membrane and enhance ROS generation ability. Notably, the membrane-targeting AIEgen namely TPS-2 induces cell death and membrane rupture via PDT to facilitate the release of antigens and activation of immune cells. Furthermore, the size-controlled TPS-2 nanoaggregates are found to serve as an adjuvant, promoting antigen accumulation and delivery to sufficiently boost the in vivo antitumor immunity by only one dose injection in a prophylactic tumor vaccination model. This work thus provides new insights into optimizing AIE photosensitizers via a hydrophobicity-hydrophilicity balance strategy for evoking an antitumor immunity and directly suppressing the distanced tumor. A single small-molecular system for PDT-stimulated antitumor immunity is envisioned
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|a Journal Article
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|a adjuvant
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|a aggregation-induced emission
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|a antitumor immunity
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|a organelle-targeting
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|a photodynamic therapy
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 700 |
1 |
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|a Yang, Xing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ou, Xinwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Michelle M S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jianyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Changhuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Xinghua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gong, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lam, Jacky W Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Pengfei
|e verfasserin
|4 aut
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| 700 |
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|a Tang, Ben Zhong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 38 vom: 14. Sept., Seite e2303186
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:38
|g day:14
|g month:09
|g pages:e2303186
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|u http://dx.doi.org/10.1002/adma.202303186
|3 Volltext
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