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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202211205
|2 doi
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|a pubmed24n1180.xml
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|a (DE-627)NLM354191314
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|a (NLM)36913539
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Yang, Yu
|e verfasserin
|4 aut
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|a Coupling Probiotics with 2D CoCuMo-LDH Nanosheets as a Tumor-Microenvironment-Responsive Platform for Precise NIR-II Photodynamic Therapy
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|c 2023
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|a Text
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 09.06.2023
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|a Date Revised 09.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains a grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics with 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as a TME-responsive platform for precise NIR-II PDT. The CoCuMo-LDH nanosheets loaded on LA can be transformed from crystalline into amorphous through etching by the LA-metabolite-enabled low pH and overexpressed glutathione. The TME-induced in situ amorphization of CoCuMo-LDH nanosheets can boost its photodynamic activity for singlet oxygen (1 O2 ) generation under 1270 nm laser irradiation with relative 1 O2 quantum yield of 1.06, which is the highest among previously reported NIR-excited PSs. In vitro and in vivo assays prove that the LA&LDH can effectively achieve complete cell apoptosis and tumor eradication under 1270 nm laser irradiation. This study proves that the probiotics can be used as a tumor-targeting platform for highly efficient precise NIR-II PDT
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|a Journal Article
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|a in situ activation
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|a layered double hydroxides
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|a photodynamic therapy
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|a probiotics
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|a tumor-microenvironment-responsive
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|a Photosensitizing Agents
|2 NLM
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|a hydroxide ion
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|a 9159UV381P
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|a Hydroxides
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|a Hu, Tingting
|e verfasserin
|4 aut
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|a Bian, Yixin
|e verfasserin
|4 aut
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|a Meng, Fanqi
|e verfasserin
|4 aut
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|a Yu, Shilong
|e verfasserin
|4 aut
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|a Li, Hai
|e verfasserin
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|a Zhang, Qinghua
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|a Gu, Lin
|e verfasserin
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|a Weng, Xisheng
|e verfasserin
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|a Tan, Chaoliang
|e verfasserin
|4 aut
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|a Liang, Ruizheng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 23 vom: 13. Juni, Seite e2211205
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:23
|g day:13
|g month:06
|g pages:e2211205
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|u http://dx.doi.org/10.1002/adma.202211205
|3 Volltext
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