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NLM348565143 |
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cr uuu---uuuuu |
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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c02433
|2 doi
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|a pubmed25n1161.xml
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|a (DE-627)NLM348565143
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|a (NLM)36342672
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|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Qi, Xiaoyu
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Nonfouling and Antibacterial Zwitterionic Contact Lenses Loaded with Heme-Mimetic Gallium Porphyrin for Treating Keratitis
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 23.11.2022
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|a Date Revised 23.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Antifouling and antibacterial are two critical challenges in the development of contact lenses (CLs). Herein, we presented nonfouling and antibacterial bifunctionalized CLs by encapsulating cationic heme-mimetic gallium porphyrin (Ga-CHP) into zwitterionic-elastomeric-networked (ZEN) hydrogel. Results proved that the ZEN hydrogel showed excellent abilities to resist non-specific protein adsorption, bacterial adhesion, and biofilm formation. Moreover, Ga-CHP could be sustainably released and kill >99.9% planktonic bacteria and >99.9% mature biofilms. In vivo, the symptoms of bacterial keratitis in mice were significantly alleviated after wearing the CLs for 7 days via iron-blocking and photodynamic synergistic antibacterial therapy with the help of natural sunlight. This study highlights the nonfouling and antibacterial superiority of the Ga-CHP-functional zwitterionic CLs and proposes a portable yet efficient non-antibiotic keratitis treatment strategy
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Gallium
|2 NLM
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|a CH46OC8YV4
|2 NLM
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|a Porphyrins
|2 NLM
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| 650 |
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|a Heme
|2 NLM
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| 650 |
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|a 42VZT0U6YR
|2 NLM
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|a Anti-Bacterial Agents
|2 NLM
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|a Hydrogels
|2 NLM
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| 700 |
1 |
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|a Zhang, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xiaowen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Hongyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Lei
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 38(2022), 46 vom: 22. Nov., Seite 14335-14344
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
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|g volume:38
|g year:2022
|g number:46
|g day:22
|g month:11
|g pages:14335-14344
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|u http://dx.doi.org/10.1021/acs.langmuir.2c02433
|3 Volltext
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