Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes A prospective randomized controlled trial

Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes : A prospective randomized controlled trial

Copyright © 2022 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 236(2022) vom: 04. März, Seite 108935
1. Verfasser: Wu, Lingling (VerfasserIn)
Weitere Verfasser: Zhao, Haiyan, Zhang, Zijing, Huang, Minli, Wu, Shuzhen, Fang, Changping, Wang, Ren, Li, Shangrong, Yi, Wei, Zhou, Andong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Acupoint injection Combined spinal-epidural anesthesia Interleukin-10 Interleukin-1β Labor analgesia Labor outcome Interleukin-1beta 130068-27-8
Beschreibung
Zusammenfassung:Copyright © 2022 Elsevier Inc. All rights reserved.
BACKGROUND: This study aimed to investigate the effects of combined spinal-epidural anesthesia (CSEA) with acupoint injection (AI) on the maternal-fetal expression of interleukin-1β (IL-1β), interleukin-10 (IL-10), analgesia effect, and labor outcomes
METHODS: A total of 360 healthy primiparas were randomized into the CSEA+AI group, the CSEA group, the AI group, and the control group (n = 90, each group) according to the labor analgesia methods
RESULTS: Compared to the CSEA group, the CSEA+AI group had significantly lower visual analog scale (VAS) scores, adverse events, dose of ropivacaine/sufentanil, and shorter labor durations. The IL-1β/IL-10 ratio in maternal peripheral blood and umbilical cord blood was reduced in the CSEA+AI group compared with the CSEA group
CONCLUSION: The combination of CSEA and AI can reduce the ratio of IL-1β/ IL-10 in maternal peripheral blood and umbilical cord blood, which can effectively relieve labor pain
Beschreibung:Date Completed 06.05.2022
Date Revised 06.05.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2022.108935