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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-021-02356-y
|2 doi
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|a pubmed24n1071.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Zheng, Rui
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Copper-induced sublethal effects in Bufo gargarizans tadpoles
|b growth, intestinal histology and microbial alternations
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| 264 |
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 27.04.2021
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|a Date Revised 27.04.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copper (Cu) is one of the environmental contaminations which can pose significant risks for organisms. The current study explores the effects of Cu exposure on the growth, intestinal histology and microbial ecology in Bufo gargarizans. The results revealed that 0.5-1 μM Cu exposure induced growth retardation (including reduction of total body length and wet weight) and intestinal histological injury (including disordered enterocyte, changes in the villi and vacuoles) of tadpoles. Also, high-throughput sequencing analysis showed that Cu exposure caused changes in richness, diversity and structure of intestinal microbiota. Moreover, the composition of intestinal microbiota was altered in tadpoles exposed to different concentrations of Cu. At the phylum level, we observed the abundance of proteobacteria was increased, while the abundance of fusobacteria was decreased in the intestinal microbiota of tadpoles exposed to 1 μM Cu. At the genus level, a reduced abundance of kluyvera and aeromonas was observed in the intestinal microbiota of tadpoles under the exposure of 0-0.5 μM Cu. Finally, functional predictions revealed that tadpoles exposed to copper may be at a higher risk of developing metabolic disorders or diseases. Above all, our results will develop a comprehensive view of the Cu exposure in amphibians and will yield a new consideration for sublethal effects of Cu on aquatic organisms
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|a Journal Article
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|a Bufo gargarizans tadpoles
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|a Cu exposure
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|a High-throughput sequencing
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|a Intestinal microbiota
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| 650 |
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|a Copper
|2 NLM
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| 650 |
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|a 789U1901C5
|2 NLM
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| 700 |
1 |
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|a Wu, Minyao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hongyuan
|e verfasserin
|4 aut
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| 700 |
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|a Chai, Lihong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Peng, Jufang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 30(2021), 3 vom: 15. Apr., Seite 502-513
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|x 1573-3017
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|g volume:30
|g year:2021
|g number:3
|g day:15
|g month:04
|g pages:502-513
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|u http://dx.doi.org/10.1007/s10646-021-02356-y
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