A framework for understanding Kawasaki disease pathogenesis
Copyright © 2020 Elsevier Inc. All rights reserved.
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 214(2020) vom: 01. Mai, Seite 108385 |
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| Auteur principal: | |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2020
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Review IL-1 IgA Inflammasome Kawasaki disease Vasculitis Immunoglobulin A Protease Inhibitors Matrix Metalloproteinases |
| Résumé: | Copyright © 2020 Elsevier Inc. All rights reserved. Kawasaki disease (KD) is a common vasculitis of childhood, typically affecting children under the age of five. Despite many aspects of its presentation that bear resemblence to acute infection, no causative infectious agent has been identified despite years of intense scrutiny. Unlike most infections, however, there are significant differences in racial predilection that suggest a strong genetic influence. The inflammatory response in KD specifically targets the coronary arteries, also unusual for an infectious condition. In this review, we discuss recent hypotheses on KD pathogenesis as well as new insights into the innate immune response and mechanisms behind vascular damage. The pathogenesis is complex, however, and remains inadequately understood |
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| Description: | Date Completed 23.10.2020 Date Revised 04.12.2021 published: Print-Electronic CommentIn: Pediatr Res. 2021 Mar;89(4):716-717. doi: 10.1038/s41390-020-0996-1. - PMID 32492695 Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2020.108385 |