Macular Capillary Perfusion in Chinese Patients With Diabetic Retinopathy Obtained With Optical Coherence Tomography Angiography

Macular Capillary Perfusion in Chinese Patients With Diabetic Retinopathy Obtained With Optical Coherence Tomography Angiography

Copyright 2019, SLACK Incorporated.

Détails bibliographiques
Publié dans:Ophthalmic surgery, lasers & imaging retina. - 2013. - 50(2019), 4 vom: 01. Apr., Seite e88-e95
Auteur principal: Yang, Dawei (Auteur)
Autres auteurs: Cao, Dan, Huang, Zhongning, Xie, Jianteng, Meng, Qianli, Dong, Xinran, Hu, Yunyan, Zeng, Yunkao, Zhang, Liang
Format: Article en ligne
Langue:English
Publié: 2019
Accès à la collection:Ophthalmic surgery, lasers & imaging retina
Sujets:Journal Article
LEADER 01000caa a22002652 4500
001 NLM296187798
003 DE-627
005 20250225053812.0
007 cr uuu---uuuuu
008 231225s2019 xx |||||o 00| ||eng c
024 7 |a 10.3928/23258160-20190401-12  |2 doi 
028 5 2 |a pubmed25n0987.xml 
035 |a (DE-627)NLM296187798 
035 |a (NLM)30998251 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Yang, Dawei  |e verfasserin  |4 aut 
245 1 0 |a Macular Capillary Perfusion in Chinese Patients With Diabetic Retinopathy Obtained With Optical Coherence Tomography Angiography 
264 1 |c 2019 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 17.12.2019 
500 |a Date Revised 17.12.2019 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a Copyright 2019, SLACK Incorporated. 
520 |a BACKGROUND AND OBJECTIVE: To compare the macular perfusion in the retina and choroidal layer between control subjects and Chinese patients with diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) and to evaluate the association of OCTA characteristics with the stage of DR 
520 |a PATIENTS AND METHODS: A total of 200 eyes (normal controls = 40; mild non-proliferative diabetic retinopathy [NPDR] = 40; moderate NPDR = 40; severe NPDR = 40; and PDR [proliferative diabetic retinopathy] = 40) underwent OCTA imaging. OCTA parameters were vessel densities in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris, as well as foveal avascular zone (FAZ) area (mm2) in the SCP 
520 |a RESULTS: The reduction of macular perfusion in the SCP, DCP, and choriocapillaris was correlated with increasing severity of DR. Vessel density in the SCP, DCP, and choriocapillaris was 55.31% ± 2.56%, 62.40% ± 2.46%, and 66.87% ± 1.30%, respectively, in control subjects; 50.58% ± 3.14%, 56.31% ± 4.24%, and 66.20% ± 1.69%, respectively, in mild NPDR; 46.46% ± 3.09%, 49.40% ± 5.68%, and 64.39% ± 1.94%, respectively, in moderate NPDR; 45.61% ± 3.81%, 49.33% ± 6.14%, and 63.75% ± 2.21%, respectively, in severe NPDR; and 43.78% ± 3.71%, 44.78% ± 6.36%, and 61.32% ± 6.29%, respectively, in PDR. Vessel density in DR groups decreased compared with normal controls (P < .001). FAZ area in the SCP was 0.34 ± 0.09 mm2 in control subjects compared with 0.48 ± 0.17 mm2 (mild NPDR), 0.52 ± 0.13 mm2 (moderate NPDR), 0.62 ± 0.24 mm2 (severe NPDR), and 0.75 ± 0.30 mm2 (PDR). FAZ in the SCP of patients with DR was greater than that in control subjects (P < .001). Vessel density in the DCP shows better ability to identify the severity of DR (area under the curve, sensitivity, and specificity of 0.967, 92.5%, and 93.1%, respectively) than vessel density in the SCP and choriocapillaris 
520 |a CONCLUSION: OCTA might be clinically useful to evaluate different stages of DR in a noninvasive manner. Vessel density in DCP could be an objective and reliable indicator for monitoring progression of DR. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e88-e95.] 
650 4 |a Journal Article 
700 1 |a Cao, Dan  |e verfasserin  |4 aut 
700 1 |a Huang, Zhongning  |e verfasserin  |4 aut 
700 1 |a Xie, Jianteng  |e verfasserin  |4 aut 
700 1 |a Meng, Qianli  |e verfasserin  |4 aut 
700 1 |a Dong, Xinran  |e verfasserin  |4 aut 
700 1 |a Hu, Yunyan  |e verfasserin  |4 aut 
700 1 |a Zeng, Yunkao  |e verfasserin  |4 aut 
700 1 |a Zhang, Liang  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Ophthalmic surgery, lasers & imaging retina  |d 2013  |g 50(2019), 4 vom: 01. Apr., Seite e88-e95  |w (DE-627)NLM224956647  |x 2325-8179  |7 nnns 
773 1 8 |g volume:50  |g year:2019  |g number:4  |g day:01  |g month:04  |g pages:e88-e95 
856 4 0 |u http://dx.doi.org/10.3928/23258160-20190401-12  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_24 
912 |a GBV_ILN_31 
912 |a GBV_ILN_40 
912 |a GBV_ILN_63 
912 |a GBV_ILN_65 
912 |a GBV_ILN_69 
912 |a GBV_ILN_70 
912 |a GBV_ILN_90 
912 |a GBV_ILN_91 
912 |a GBV_ILN_130 
912 |a GBV_ILN_135 
912 |a GBV_ILN_136 
912 |a GBV_ILN_151 
912 |a GBV_ILN_181 
912 |a GBV_ILN_203 
912 |a GBV_ILN_217 
912 |a GBV_ILN_235 
912 |a GBV_ILN_289 
912 |a GBV_ILN_294 
912 |a GBV_ILN_297 
912 |a GBV_ILN_350 
912 |a GBV_ILN_352 
912 |a GBV_ILN_674 
912 |a GBV_ILN_676 
912 |a GBV_ILN_688 
912 |a GBV_ILN_698 
912 |a GBV_ILN_721 
912 |a GBV_ILN_737 
912 |a GBV_ILN_791 
912 |a GBV_ILN_812 
951 |a AR 
952 |d 50  |j 2019  |e 4  |b 01  |c 04  |h e88-e95