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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b03196
|2 doi
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|a pubmed25n0977.xml
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|a (DE-627)NLM293391556
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|a (NLM)30712354
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Saha Ray, Arunendra
|e verfasserin
|4 aut
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|a Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.06.2020
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|a Date Revised 22.06.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The synthesis of a novel poly(propyleneimine) (PPI) dendron in gram scale as well as its use in the formation of a highly stable, dendronized gold nanoparticle (AuNP)-based drug delivery platform is described herein. The AuNP-based platform is composed of three complementary parts: (i) a 15 nm AuNP core, (ii) a heterofunctional thioctic acid-terminated tetraethylene glycol spacer, and (iii) a third-generation PPI dendron with a unique protonation profile and diverse end-group functionalization that allows for further derivatization. The prepared dendronized AuNPs are able to withstand several rounds of lyophilization cycles with no sign of aggregation, are stable in phosphate-buffered saline and Hanks' buffer as well as in serum, and are resistant to degradation by glutathione exchange reactions. This nanocarrier platform displays a dense coating, with >1400 dendrons/AuNPs, which will enable very high payload. Furthermore, while amine-terminated AuNPs expectedly showed cytotoxicity against the MCF-7 breast cancer cell line from a NP concentration of 1 nM, the mixed monolayer AuNPs (coated with 40/60 amine/carboxylate dendrons) interestingly did not exhibit any sign of toxicity at concentrations as high as 15 nM, similar to the carboxylate-terminated AuNPs. The described dendronized AuNPs address the current practical need for a stable NP-based drug delivery platform which is scalable and easily conjugable, has long-term stability in solution, and can be conveniently formulated as a powder and redispersed in desired buffer or serum
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Dendrimers
|2 NLM
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|a Polypropylenes
|2 NLM
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|a Propionates
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|a poly(propyleneimine)
|2 NLM
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|a Thioctic Acid
|2 NLM
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|a 73Y7P0K73Y
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Ghann, William E
|e verfasserin
|4 aut
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|a Tsoi, Phoebe S
|e verfasserin
|4 aut
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|a Szychowski, Brian
|e verfasserin
|4 aut
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|a Dockery, Lance T
|e verfasserin
|4 aut
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|a Pak, Yewon J
|e verfasserin
|4 aut
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|a Li, Wenjing
|e verfasserin
|4 aut
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|a Kane, Maureen A
|e verfasserin
|4 aut
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|a Swaan, Peter
|e verfasserin
|4 aut
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|a Daniel, Marie-Christine
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 35(2019), 9 vom: 05. März, Seite 3391-3403
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
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|g volume:35
|g year:2019
|g number:9
|g day:05
|g month:03
|g pages:3391-3403
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|u http://dx.doi.org/10.1021/acs.langmuir.8b03196
|3 Volltext
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|d 35
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|h 3391-3403
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