Suprachoroidal Space Alterations Following Delivery of Triamcinolone Acetonide Post-Hoc Analysis of the Phase 1/2 HULK Study of Patients With Diabetic Macular Edema

Suprachoroidal Space Alterations Following Delivery of Triamcinolone Acetonide : Post-Hoc Analysis of the Phase 1/2 HULK Study of Patients With Diabetic Macular Edema

Copyright 2018, SLACK Incorporated.

Bibliographische Detailangaben
Veröffentlicht in:Ophthalmic surgery, lasers & imaging retina. - 2013. - 49(2018), 9 vom: 01. Sept., Seite 692-697
1. Verfasser: Lampen, Shaun I R (VerfasserIn)
Weitere Verfasser: Khurana, Rahul N, Noronha, Glenn, Brown, David M, Wykoff, Charles C
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Ophthalmic surgery, lasers & imaging retina
Schlagworte:Clinical Trial, Phase I Clinical Trial, Phase II Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Glucocorticoids Triamcinolone Acetonide F446C597KA
Beschreibung
Zusammenfassung:Copyright 2018, SLACK Incorporated.
BACKGROUND AND OBJECTIVE: To study anatomic changes in the suprachoroidal space (SCS) following suprachoroidal injection of CLS-TA, triamcinolone acetonide injectable suspension
PATIENTS AND METHODS: Eyes with diabetic macular edema receiving CLS-TA were imaged serially using anterior segment spectral-domain optical coherence tomography to examine the SCS
RESULTS: At the final imaging session, the SCS was not significantly different in study eyes (n = 14; 8.4 μm) compared to fellow eyes (n = 10; 8.1 μm; P = .698). Two eyes were imaged immediately before and 30 minutes after suprachoroidal injections; in these eyes, mean suprachoroidal width increased significantly following CLS-TA injection, 9.9 μm to 75.1 μm (P < .001), and subsequently returned to 14.9 μm 1 month after the final injection (P = .221)
CONCLUSION: Suprachoroidal CLS-TA injection caused a measurable increase in the SCS, which returned to preinjection levels by 1 month following injection with no apparent lasting impact on SCS anatomy. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:692-697.]
Beschreibung:Date Completed 15.03.2019
Date Revised 15.03.2019
published: Print
Citation Status MEDLINE
ISSN:2325-8179
DOI:10.3928/23258160-20180831-07