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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201801065
|2 doi
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|a pubmed25n0946.xml
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|a (DE-627)NLM284128929
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|a (NLM)29766581
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Gu, Xinggui
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Corannulene-Incorporated AIE Nanodots with Highly Suppressed Nonradiative Decay for Boosted Cancer Phototheranostics In Vivo
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.03.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Fluorescent nanoparticles (NPs) based on luminogens with aggregation-induced emission characteristic (AIEgens), namely AIE dots, have received wide attention because of their antiquenching attitude in emission and reactive oxygen species (ROS) generation when aggregated. However, few reports are available on how to control and optimize their fluorescence and ROS generation ability. Herein, it is reported that enhancing the intraparticle confined microenvironment is an effective approach to advanced AIE dots, permitting boosted cancer phototheranostics in vivo. Formulation of a "rotor-rich" and inherently charged near-infrared (NIR) AIEgen with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] and corannulene-decorated PEG affords DSPE-AIE dots and Cor-AIE dots, respectively. Compared to DSPE-AIE dots, Cor-AIE dots show 4.0-fold amplified fluorescence quantum yield and 5.4-fold enhanced ROS production, because corannulene provides intraparticle rigidity and strong interactions with the AIEgen to restrict the intramolecular rotation of AIEgen to strongly suppress the nonradiative decay and significantly facilitate the fluorescence pathway and intersystem crossing. Thus, it tremendously promotes phototheranostic efficacies in terms of NIR image-guided cancer surgery and photodynamic therapy using a peritoneal carcinomatosis-bearing mouse model. Collectively, it not only provides a novel strategy to advanced AIE dots for cancer phototheranostics, but also brings new insights into the design of superior fluorescent NPs for biomedical applications
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|a Journal Article
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|a AIE nanodots
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|a aggregation-induced emission
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|a cancer phototheranostics
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| 650 |
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|a near-infrared fluorescence image-guided surgery
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|a photodynamic therapy
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|a Polycyclic Aromatic Hydrocarbons
|2 NLM
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| 650 |
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|a corannulene
|2 NLM
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| 700 |
1 |
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|a Zhang, Xiaoyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Huili
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Shaorui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Pengfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yanjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jianguo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Xiaoyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lam, Jacky W Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Dan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Ben Zhong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 26 vom: 11. Juni, Seite e1801065
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2018
|g number:26
|g day:11
|g month:06
|g pages:e1801065
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201801065
|3 Volltext
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