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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b00626
|2 doi
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|a eng
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| 100 |
1 |
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|a Hao, Lingxia
|e verfasserin
|4 aut
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|a pH-Responsive Zwitterionic Copolymer DHA-PBLG-PCB for Targeted Drug Delivery
|b A Computer Simulation Study
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 08.06.2020
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|a Date Revised 08.06.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In this work, the self-assembled behaviors of zwitterionic copolymer docosahexaenoic acid- b-poly(γ-benzyl-l-glutamate)- b-poly(carboxybetaine methacrylate) (DHA-PBLG-PCB) and the loading and release mechanism of the anticancer drug doxorubicin (DOX) was investigated via computer simulations. The effects of polymer concentration, drug content, and pH on polymeric micelles were explored by dissipative particle dynamics (DPD) simulations. Simulation results show that DHA-PBLG15-PCB10 can self-assemble into core-shell micelles; in addition, the drug-loaded micelles have a pH-responsive feature. DOX can be encapsulated into the core-shell micelle under normal physiological pH conditions, whereas it can be released under acidic pH conditions. The self-assembled behaviors of copolymer DHA-PBLG-PEG were also studied to have a comparison with those of DHA-PBLG-PCB. The DHA-PBLG15-PCB10 system has a stable structure and it has a great potential to serve as drug delivery vehicles for targeted drug delivery
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antineoplastic Agents
|2 NLM
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|a Drug Carriers
|2 NLM
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|a Micelles
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|a Polymethacrylic Acids
|2 NLM
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|a Polyglutamic Acid
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|a 25513-46-6
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|a Doxorubicin
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|a Lin, Lin
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|a Zhou, Jian
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 5 vom: 05. Feb., Seite 1944-1953
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|g year:2019
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|g month:02
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