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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.12.002
|2 doi
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|a pubmed24n0929.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Knoop, Jan
|e verfasserin
|4 aut
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| 245 |
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|a GM-CSF producing autoreactive CD4+ T cells in type 1 diabetes
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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| 500 |
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|a Date Completed 22.04.2019
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|a Date Revised 22.04.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
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|a The phenotype of autoreactive T cells in type 1 diabetes is described as Th1, Th17 and/or Th21, but is largely uncharacterized. We combined multi-parameter cytokine profiling and proliferation, and identified GM-CSF producing cells as a component of the response to beta cell autoantigens proinsulin and GAD65. Overall cytokine profiles of CD4+ T cell were not altered in type 1 diabetes. In contrast, patients with recent onset type 1 diabetes had increased frequencies of proinsulin-responsive CD4+CD45RA- T cells producing GM-CSF (p=0.002), IFNγ (p=0.004), IL-17A (p=0.008), IL-21 (p=0.011), and IL-22 (p=0.007), and GAD65-responsive CD4+CD45RA- T cells producing IL-21 (p=0.039). CD4+ T cells with a GM-CSF+IFNγ-IL-17A-IL-21-IL-22- phenotype were increased in patients for responses to both proinsulin (p=0.006) and GAD65 (p=0.037). GM-CSF producing T cells are a novel phenotype in the repertoire of T helper cells in type 1 diabetes and consolidate a Th1/Th17 pro-inflammatory pathogenesis in the disease
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Autoreactive T cells
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|a Cytokines
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|a GM-CSF
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|a Memory CD4(+) T cell
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|a TH1 immunity
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|a Type 1 diabetes
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|a Autoantigens
|2 NLM
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|a Cytokines
|2 NLM
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| 650 |
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|a Granulocyte-Macrophage Colony-Stimulating Factor
|2 NLM
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| 650 |
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|a 83869-56-1
|2 NLM
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| 650 |
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|a Proinsulin
|2 NLM
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| 650 |
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|a 9035-68-1
|2 NLM
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| 650 |
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|a Glutamate Decarboxylase
|2 NLM
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| 650 |
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| 700 |
1 |
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|a Gavrisan, Anita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kuehn, Denise
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reinhardt, Julia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heinrich, Melanie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hippich, Markus
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eugster, Anne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ockert, Christian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ziegler, Anette-Gabriele
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bonifacio, Ezio
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 188(2018) vom: 10. März, Seite 23-30
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|x 1521-7035
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|g volume:188
|g year:2018
|g day:10
|g month:03
|g pages:23-30
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|u http://dx.doi.org/10.1016/j.clim.2017.12.002
|3 Volltext
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