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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1155/2016/6404082
|2 doi
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|a eng
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| 100 |
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|a Gagolewicz, Peter J
|e verfasserin
|4 aut
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| 245 |
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|a Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 30.12.2016
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The rodent primary visual cortex (V1) is densely innervated by serotonergic axons and previous in vitro work has shown that serotonin (5-HT) can modulate plasticity (e.g., long-term potentiation (LTP)) at V1 synapses. However, little work has examined the effects of 5-HT on LTP under in vivo conditions. We examined the role of 5-HT on LTP in V1 elicited by theta burst stimulation (TBS) of the lateral geniculate nucleus in urethane-anesthetized (adult and juvenile) rats. Thalamic TBS consistently induced potentiation of field postsynaptic potentials (fPSPs) recorded in V1. While 5-HT application (0.1-10 mM) itself did not alter LTP levels, the broad-acting 5-HT receptor antagonists methiothepin (1 mM) resulted in a clear facilitation of LTP in adult animals, an effect that was mimicked by the selective 5-HT1A receptor antagonist WAY 100635 (1 mM). Interestingly, in juvenile rats, WAY 100635 application inhibited LTP, indicative of an age-dependent switch in the role of 5-HT1A receptors in gating V1 plasticity. Analyses of spontaneous electrocorticographic (ECoG) activity in V1 indicated that the antagonist-induced LTP enhancement was not related to systematic changes in oscillatory activity in V1. Together, these data suggest a facilitating role of 5-HT1A receptor activation on LTP in the juvenile V1, which switches to a tonic, inhibitory influence in adulthood
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Piperazines
|2 NLM
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|a Pyridines
|2 NLM
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|a Serotonin Antagonists
|2 NLM
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|a Receptor, Serotonin, 5-HT1A
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|a 112692-38-3
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|a Serotonin
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| 650 |
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|a 333DO1RDJY
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| 650 |
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|a Methiothepin
|2 NLM
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| 650 |
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|a 55D94103HL
|2 NLM
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| 650 |
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|a N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
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| 650 |
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| 700 |
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|a Dringenberg, Hans C
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2016(2016) vom: 28., Seite 6404082
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|g volume:2016
|g year:2016
|g day:28
|g pages:6404082
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|u http://dx.doi.org/10.1155/2016/6404082
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