Through-space (19) F-(15) N couplings for the assignment of stereochemistry in flubenzimine
Copyright © 2016 John Wiley & Sons, Ltd.
| Publié dans: | Magnetic resonance in chemistry : MRC. - 1985. - 54(2016), 7 vom: 01. Juli, Seite 592-6 |
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| Auteur principal: | |
| Autres auteurs: | , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2016
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| Accès à la collection: | Magnetic resonance in chemistry : MRC |
| Sujets: | Journal Article 15N 19F NMR coupling constant flubenzimine stereochemistry through-space coupling Amino Acids Imines plus... |
| Résumé: | Copyright © 2016 John Wiley & Sons, Ltd. Through-space (19) F-(15) N couplings revealed the configuration of flubenzimine, with the CF3 group on N4 pointing towards the lone pair of N5. The (19) F-(15) N coupling constants were measured at natural abundance using a spin-state selective indirect-detection pulse sequence. As (15) N-labelled proteins are routinely synthesized for NMR studies, through-space (19) F-(15) N couplings have the potential to probe the stereochemistry of these proteins by (19) F labelling of some amino acids or can reveal the site of docking of fluorine-containing drugs. Copyright © 2016 John Wiley & Sons, Ltd |
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| Description: | Date Completed 08.02.2018 Date Revised 08.02.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.4407 |