NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 28(2016), 2 vom: 13. Jan., Seite 245-53 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2016
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't NIR lasers chemotherapy photothermal therapy smart nanocapsules switches tumors Antineoplastic Agents Nanocapsules mehr... |
| Zusammenfassung: | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. In vivo MEO2 MAMEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately |
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| Beschreibung: | Date Completed 15.12.2016 Date Revised 18.03.2022 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.201502669 |