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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.12296
|2 doi
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|a pubmed25n0804.xml
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|a eng
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|a Braceland, M
|e verfasserin
|4 aut
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| 245 |
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|a Serum enolase
|b a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 05.04.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2014 John Wiley & Sons Ltd.
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|a Diseases which cause skeletal muscle myopathy are some of the most economically damaging diseases in Atlantic salmon, Salmo salar L., aquaculture. Despite this, there are limited means of assessing fish health non-destructively. Previous investigation of the serum proteome of Atlantic salmon, Salmo salar L., during pancreas disease (PD) has identified proteins in serum that have potential as biomarkers of the disease. Amongst these proteins, the enzyme enolase was selected as the most viable for use as a biomarker of muscle myopathy associated with PD. Western blot and immunoassay (ELISA) validated enolase as a biomarker for PD, whilst immunohistochemistry identified white muscle as the source of enolase. Enolase was shown to be a specific marker for white muscle myopathy in salmon, rising in serum concentration significantly correlating with pathological damage to the tissue
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Atlantic salmon
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|a biomarkers
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|a enolase
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|a health
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|a myopathy
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|a pancreas disease
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| 650 |
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|a Biomarkers
|2 NLM
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|a Phosphopyruvate Hydratase
|2 NLM
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| 700 |
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|a McLoughlin, M F
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|4 aut
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|a Tinsley, J
|e verfasserin
|4 aut
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|a Wallace, C
|e verfasserin
|4 aut
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| 700 |
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|a Cockerill, D
|e verfasserin
|4 aut
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| 700 |
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|a McLaughlin, M
|e verfasserin
|4 aut
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| 700 |
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|a Eckersall, P D
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 38(2015), 9 vom: 22. Sept., Seite 821-31
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|x 1365-2761
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|g volume:38
|g year:2015
|g number:9
|g day:22
|g month:09
|g pages:821-31
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|u http://dx.doi.org/10.1111/jfd.12296
|3 Volltext
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