Binding of a monoclonal antibody to the phospholamban cytoplasmic domain interferes with the channel activity of phospholamban reconstituted in a tethered bilayer lipid membrane

Phospholamban (PLN), a membrane protein present in the sarcoplasmic reticulum of cardiac myocytes, is a crucial regulator of cardiac function. It is known that PLN appears as a monomer and as a pentamer. However, the role of the PLN pentamer and its ability to generate an ion channel are a matter of...

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Publié dans:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 30(2014), 34 vom: 02. Sept., Seite 10384-8
Auteur principal:	Smeazzetto, Serena (Auteur)
Autres auteurs:	Sacconi, Alessio, Schwan, Adrian L, Margheri, Giancarlo, Tadini-Buoninsegni, Francesco
Format:	Article en ligne
Langue:	English
Publié:	2014
Accès à la collection:	Langmuir : the ACS journal of surfaces and colloids
Sujets:	Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Calcium-Binding Proteins Lipid Bilayers phospholamban