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|a 10.5713/ajas.2012.12703
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|a eng
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| 100 |
1 |
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|a Patra, Manas Kumar
|e verfasserin
|4 aut
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| 245 |
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|a Neutrophil functions and cytokines expression profile in buffaloes with impending postpartum reproductive disorders
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|c 2013
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|a Text
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|a Date Completed 22.07.2014
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|a Date Revised 18.03.2022
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a The study was conducted to correlate the periparturient immune status in terms of neutrophil functions and cytokine expression in peripheral blood mononuclear cell culture with impending postpartum reproductive disorders in buffaloes. Forty pregnant buffaloes were observed for occurrence of postpartum reproductive disorders (PRD), i.e., metritis, endometritis and delayed uterine involution etc., during one week prepartum to four weeks postpartum period. A representative number (n = 6) of buffaloes that did not develop any PRD were included in group I (healthy, control), while the animals which experienced PRD were assigned into group II (PRD, n = 8). The blood samples were collected at weekly interval from one week prepartum to four weeks postpartum period considering the day of calving as 'd 0'. Differential leucocytes counts, superoxide and hydrogen peroxide production activity in isolated neutrophils and the mRNA expression profile of cytokines i.e., IL-2, IL-4 and IFN-γ in PBMC culture were studied in all the samples. A higher total leucocytes, neutrophil and band cells count along with impaired neutrophil functions i.e., lowered level of production of superoxide and hydrogen peroxide before parturition and during early postpartum period were observed in buffaloes developing PRD. Further, a lower expression of IL-2, IFN-γ and IL-4 mRNA in PBMC culture was observed at calving in buffaloes that subsequently developed PRD at later postpartum. Thus, suppression in neutrophil function and cytokine expression at prepartum to early postpartum period predisposes the buffaloes to develop postpartum reproductive disorders. Hence, monitoring of neutrophils function and cytokine expression profile would be effective to predict certain reproductive disorders at late pregnancy or immediately after parturition in buffaloes. In future, this may be a novel approach for determining suitable management and therapeutic decisions for prevention of commonly occurring reproductive disorders in farm animals
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|a Journal Article
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|a Cytokine Expression
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|a Lymphocytes
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|a Neutrophil Functions
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|a Postpartum Buffalo
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| 650 |
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|a Reproductive Disorder
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| 700 |
1 |
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|a Kumar, Harendra
|e verfasserin
|4 aut
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1 |
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|a Nandi, Sukdeb
|e verfasserin
|4 aut
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|i Enthalten in
|t Asian-Australasian journal of animal sciences
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|g 26(2013), 10 vom: 24. Okt., Seite 1406-15
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|g pages:1406-15
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