Correlation between ultrasound diagnosis and autopsy findings of fetal malformations

OBJECTIVE: to compare ultrasound (US) and autopsy findings of fetal malformations in second trimester terminations of pregnancy to evaluate the degree of agreement between US and fetal autopsy

Bibliographische Detailangaben
Veröffentlicht in:Journal of prenatal medicine. - 2007. - 6(2012), 2 vom: 26. Apr., Seite 13-7
1. Verfasser: Vimercati, Antonella (VerfasserIn)
Weitere Verfasser: Grasso, Silvana, Abruzzese, Marinella, Chincoli, Annarosa, de Gennaro, Alessandra, Miccolis, Angela, Serio, Gabriella, Selvaggi, Luigi, Fascilla, Fabiana Divina
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Journal of prenatal medicine
Schlagworte:Journal Article fetal autopsy fetal malformations prenatal diagnosis prenatal ultrasound
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500 |a Date Revised 21.10.2021 
500 |a published: Print 
500 |a Citation Status PubMed-not-MEDLINE 
520 |a OBJECTIVE: to compare ultrasound (US) and autopsy findings of fetal malformations in second trimester terminations of pregnancy to evaluate the degree of agreement between US and fetal autopsy 
520 |a METHODS: in this study, all second trimester termination of pregnancy between 2003-2010 were considered. US and autopsy findings were compared and all cases were classified into five categories according to the degree of agreement between US and pathology (A1: full agreement between US and autopsy; A2: autopsy confirmed all US findings but revealed additional anomalies 'rarely detectable' prenatally; B: autopsy demonstrated all US findings but revealed additional anomalies 'detectable' prenatally; C: US findings were only partially demonstrated at fetal autopsy; D: total disagreement between US and autopsy) 
520 |a RESULTS: 144 cases were selected. In 49% of cases there was total agreement between US and autopsy diagnosis (A1). In 22% of cases additional information were about anomalies 'not detectable' by US (A2). In 12% of cases autopsy provided additional information about anomalies not observed but 'detectable' by US (B). In 13% of cases some anomalies revealed at US, such as valve insufficiencies, pericardial and pleural effusions, were not verified at autopsy (C). Total lack of agreement was noted only in 4% of cases (D). Main areas of disagreement concerned cardiovascular, CNS and complex malformations. The degree of agreement was higher if malformations were diagnosed in a tertiary center 
520 |a CONCLUSIONS: this study shows an overall high degree of agreement between definitive US and autopsy findings in second trimester termination of pregnancy for fetal malformations. Autopsy reveals to be the best tool to diagnose malformations and often showed other abnormalities of clinical importance not detected by US, but sometimes also US could provide additional information about functional anomalies because US is a dynamic examination 
650 4 |a Journal Article 
650 4 |a fetal autopsy 
650 4 |a fetal malformations 
650 4 |a prenatal diagnosis 
650 4 |a prenatal ultrasound 
700 1 |a Grasso, Silvana  |e verfasserin  |4 aut 
700 1 |a Abruzzese, Marinella  |e verfasserin  |4 aut 
700 1 |a Chincoli, Annarosa  |e verfasserin  |4 aut 
700 1 |a de Gennaro, Alessandra  |e verfasserin  |4 aut 
700 1 |a Miccolis, Angela  |e verfasserin  |4 aut 
700 1 |a Serio, Gabriella  |e verfasserin  |4 aut 
700 1 |a Selvaggi, Luigi  |e verfasserin  |4 aut 
700 1 |a Fascilla, Fabiana Divina  |e verfasserin  |4 aut 
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