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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2011.04.016
|2 doi
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|a pubmed24n0696.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a He, Chunyan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effects of oligodeoxynucleotide with CCT repeats on chronic graft versus host disease induced experimental lupus nephritis in mice
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 19.10.2011
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|a Date Revised 22.08.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a A synthesized single-stranded oligodeoxynucleotide (ODN), designed as SAT05f with the sequence of human microsatellite DNA, has been studied for its capacity of alleviating the lupus nephritis in the chronic graft versus host disease (cGVHD) induced lupus-prone mice. In cGVHD model mice, both of continuous and discontinuous treatment with SAT05f was effective on reducing anti-ssDNA antibody production, decreasing renal IgG deposition and delaying the onset of lupus nephritis. In addition, SAT05f could down-regulate TLR9 mRNA expression in splenocytes of cGVHD model mice. These results indicated that SAT05f could be developed as a new therapeutic agent for the treatment of lupus nephritis by inhibiting TLR9 signaling pathways
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a DNA, Single-Stranded
|2 NLM
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|a Immunoglobulin G
|2 NLM
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| 650 |
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|a Oligodeoxyribonucleotides
|2 NLM
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| 650 |
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|a SAT05f
|2 NLM
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| 650 |
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|a Tlr9 protein, mouse
|2 NLM
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| 650 |
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|a Toll-Like Receptor 9
|2 NLM
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| 700 |
1 |
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|a Zhou, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Ran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Tiesuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yongsheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Yao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Liying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Yongli
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 140(2011), 3 vom: 01. Sept., Seite 300-6
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:140
|g year:2011
|g number:3
|g day:01
|g month:09
|g pages:300-6
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|u http://dx.doi.org/10.1016/j.clim.2011.04.016
|3 Volltext
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