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|a 10.1016/j.clim.2010.12.016
|2 doi
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|a pubmed25n1430.xml
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|a eng
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| 100 |
1 |
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|a Ke, Yan
|e verfasserin
|4 aut
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|a Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-β dependent regulatory T cells
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 14.04.2011
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|a Date Revised 29.05.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a Chronic/recurrent autoimmune (idiopathic) uveitis is difficult to treat and they account for approximately 10% of legal blindness in the Western world. As it has been reported that anti-CD3 antibody can enhance T cell regulatory function, we investigated its effects in vivo on experimental autoimmune uveitis (EAU), a model for autoimmune uveitis in humans. B10RIII mice immunized with an uveitogenic peptide were treated with the F(ab')(2) fragment of anti-CD3 mAb either before or at clinical disease onset. Evaluation of EAU and cellular responses showed that disease was inhibited and the activation and expansion of pathogenic T cells selectively reduced, whereas functions of Treg in vivo were enhanced. Moreover, mice treated with anti-CD3 mAb were resistant to a second challenge with antigen and thus protected from recurrence of disease. Our results demonstrate that anti-CD3 mAb is a potent inhibitor of autoimmune uveitis
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Antibodies, Monoclonal
|2 NLM
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|a CD3 Complex
|2 NLM
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|a IL10 protein, mouse
|2 NLM
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| 650 |
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|a Transforming Growth Factor beta
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 700 |
1 |
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|a Jiang, Guomin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Deming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kaplan, Henry J
|e verfasserin
|4 aut
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| 700 |
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|a Shao, Hui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 3 vom: 25. März, Seite 311-20
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:138
|g year:2011
|g number:3
|g day:25
|g month:03
|g pages:311-20
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|u http://dx.doi.org/10.1016/j.clim.2010.12.016
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