Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth

Peptides have been shown to mediate the reduction and clustering of inorganic ions during biomineralization processes to build nanomaterials with well-defined shape, size, and composition. This precise control has been linked to specific amino acid sequence; however, there is a lack of information a...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 25(2009), 18 vom: 15. Sept., Seite 10886-92
1. Verfasser: Stanley, Scott K (VerfasserIn)
Weitere Verfasser: Becker, Matthew L, Lin, Eric K, Wu, Wen-li
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Buffers Chlorides Gold Compounds Peptides Citric Acid 2968PHW8QP Gold mehr... 7440-57-5 gold tetrachloride, acid 8H372EGX3V HEPES RWW266YE9I
Beschreibung
Zusammenfassung:Peptides have been shown to mediate the reduction and clustering of inorganic ions during biomineralization processes to build nanomaterials with well-defined shape, size, and composition. This precise control has been linked to specific amino acid sequence; however, there is a lack of information about the role of peptides during mineralization. Here, we investigate the nucleation and growth behavior of Au nanocrystals that are mediated by the engineered peptide AYSSGAPPMPPF. Unlike other nanocrystal synthesis schemes, this peptide produces Au nanocrystals from Au(III) ions at very low relative peptide concentrations, at ambient temperature, and in water at neutral pH. Our data show that (i) the peptide AYSSGAPPMPPF actually inhibits nucleation and growth of nanocrystals, (ii) HEPES plays an active chemical role as the reducing agent, and (iii) HAuCl4 accelerates the kinetics of nanoparticle nucleation and growth. Herein, we propose empirical rate laws for nucleation and growth of Au nanocrystals and compare kinetic rate laws for this peptide, citrate, and various other polymer ligands. We find that the peptide belongs to a unique class of nonreducing inhibitor ligands regulating the surface-reaction-limited growth of nanocrystals
Beschreibung:Date Completed 04.12.2009
Date Revised 23.11.2015
published: Print
Citation Status MEDLINE
ISSN:1520-5827
DOI:10.1021/la901222k