Intravenous immunoglobulin G-mediated inhibition of T-cell proliferation reflects an endogenous mechanism by which IgG modulates T-cell activation

Commercial intravenous immunoglobulin G (IVIG) at high doses has therapeutic benefit in autoimmune and inflammatory diseases. It has been shown to inhibit T-cell function but the mechanisms are unclear. Inhibition could result from IVIG processing, donor pooling or intrinsic downregulatory activity...

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Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 2 vom: 01. Aug., Seite 222-33
Auteur principal:	MacMillan, Heather F (Auteur)
Autres auteurs:	Lee, Tim, Issekutz, Andrew C
Format:	Article en ligne
Langue:	English
Publié:	2009
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal CD28 Antigens CD3 Complex Immunoglobulin Fab Fragments Immunoglobulin G Immunoglobulins, Intravenous Receptors, Antigen, T-Cell