Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates : effect of pH and aging and cytotoxicity studies

We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temperature from mixtures of single-chain biocompatible commercially available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphological...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1985. - 24(2008), 18 vom: 16. Sept., Seite 9983-8
1. Verfasser: Vlachy, N (VerfasserIn)
Weitere Verfasser: Merle, C, Touraud, D, Schmidt, J, Talmon, Y, Heilmann, J, Kunz, W
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Biocompatible Materials Carboxylic Acids Lauric Acids Lipid Bilayers Surface-Active Agents Tetrazolium Salts Thiazoles lauric acid mehr... 1160N9NU9U thiazolyl blue EUY85H477I Hydrochloric Acid QTT17582CB
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245 1 0 |a Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates  |b effect of pH and aging and cytotoxicity studies 
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520 |a We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temperature from mixtures of single-chain biocompatible commercially available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphological transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate and sodium laurate. The effect of aging of the mixed surfactant systems in the pH region desired for dermatologic application (4.5 < pH < 7) is also studied. Finally, we show results of cytotoxicity studies on the surfactant mixtures 
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700 1 |a Merle, C  |e verfasserin  |4 aut 
700 1 |a Touraud, D  |e verfasserin  |4 aut 
700 1 |a Schmidt, J  |e verfasserin  |4 aut 
700 1 |a Talmon, Y  |e verfasserin  |4 aut 
700 1 |a Heilmann, J  |e verfasserin  |4 aut 
700 1 |a Kunz, W  |e verfasserin  |4 aut 
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