Topology of a ternary complex (proparacaine-beta-cyclodextrin-liposome) by STD NMR

2008 John Wiley & Sons, Ltd.

Détails bibliographiques
Publié dans:Magnetic resonance in chemistry : MRC. - 1985. - 46(2008), 9 vom: 01. Sept., Seite 832-7
Auteur principal: Cabeça, Luís Fernando (Auteur)
Autres auteurs: Fernandes, Sergio Antonio, de Paula, Eneida, Marsaioli, Anita Jocelyne
Format: Article en ligne
Langue:English
Publié: 2008
Accès à la collection:Magnetic resonance in chemistry : MRC
Sujets:Journal Article Research Support, Non-U.S. Gov't Liposomes beta-Cyclodextrins proxymetacaine B4OB0JHI1X Propoxycaine EPD1EH7F53 betadex JV039JZZ3A
Description
Résumé:2008 John Wiley & Sons, Ltd.
The topologies of proparacaine (PPC) in beta-cyclodextrin (beta-CD), PPC in egg phosphatidylcholine (EPC) liposomes and PPC in beta-CD in EPC were investigated using NMR experiments (1D ROESY and saturation transfer difference (STD)). This is the first description of the STD technique applied to PPC-EPC-beta-CD system, revealing that not only PPC was imbedded in EPC bilayer, but beta-CD was also interacting with liposome vesicles. These results are novel and were rationalized as the spontaneous formation of a ternary complex with some beta-CD molecules bound to external liposome vesicles surfaces
Description:Date Completed 30.10.2008
Date Revised 21.11.2013
published: Print
Citation Status MEDLINE
ISSN:1097-458X
DOI:10.1002/mrc.2265