Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways

Visilizumab, a humanized low-Fc receptor binding anti-CD3 antibody, induces rapid clinical response in patients with steroid-refractory ulcerative colitis (UC). Several effective treatments in IBD have been linked to the induction of mucosal T cell apoptosis. The aim of the present study was to eval...

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Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 127(2008), 3 vom: 01. Juni, Seite 322-9
Auteur principal:	Yu, Qi T (Auteur)
Autres auteurs:	Saruta, Masayuki, Papadakis, Konstantinos A
Format:	Article en ligne
Langue:	English
Publié:	2008
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Apoptosis Regulatory Proteins CD3 Complex Enzyme Inhibitors Caspase 3 EC 3.4.22.- Caspase 8 visilizumab H18SKU3289