Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

The cytoplasmic repressor Keap1 regulates the function of transcription factor Nrf2 which plays critical roles in oxidative and xenobiotic stresses. The Neh2 domain of Nrf2 interacts with Keap1 at the bottom region of the Kelch/beta-propeller domain which is formed by double-glycine repeat and C-ter...

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Veröffentlicht in:	Journal of synchrotron radiation. - 1994. - 15(2008), Pt 3 vom: 07. Mai, Seite 273-6
1. Verfasser:	Padmanabhan, Balasundaram (VerfasserIn)
Weitere Verfasser:	Tong, Kit I, Kobayashi, Akira, Yamamoto, Masayuki, Yokoyama, Shigeyuki
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2008
Zugriff auf das übergeordnete Werk:	Journal of synchrotron radiation
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Adaptor Proteins, Signal Transducing Cytoskeletal Proteins Keap1 protein, mouse Kelch-Like ECH-Associated Protein 1 NF-E2-Related Factor 2 Nfe2l2 protein, mouse