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DE-627 |
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231223s2008 xx ||||| 00| ||chi c |
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|a pubmed25n0597.xml
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|a (DE-627)NLM178999423
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|a (NLM)18419955
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Zhang, Rui-hong
|e verfasserin
|4 aut
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|a Effects of different delivery routes of CD34+ stem cells on cardiac function in the ischemic cardiomyopathy of rats
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 05.01.2010
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|a Date Revised 18.04.2008
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To compare the effects of CD34-positive stem cells delivered by different routes on cardiac function in rats with ischemic cardiomyopathy, and to evaluate the efficacy and safety of stem cell transplantation
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|a METHODS: Sixty-four male Wistar rats were randomized into cell infusion group (n=30), acute myocardial infarction (AMI) model group (n=20) and sham operation group (n=14). AMI model was reproduced by ligation of left anterior descending coronary artery. CD34+ stem cells mobilized with granulocyte-colony stimulating factor (G-CSF) were purified by immunomagnetic beads in 30 donor rats. Seven days after the injury about (7-9)x10(7) CD34+ stem cells were infused through the femoral vein or through epicardium of recipient rats respectively. Cardiac function was evaluated before AMI, 1, 2 and 4 weeks after cell delivery. Hemodynamic parameters were determined 4 weeks after cell infusion
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|a RESULTS: Compared with model group, left ventricular ejection fraction(LVEF), fractional shortening (DeltaFS), left ventricular end-systolic pressure (LVESP) and maximal positive change in filling pressure versus time (+dp/dt max) were improved significantly (all P<0.01), whereas left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic pressure (LVEDP), maximal negative change in filling pressure versus time (-dp/dt max), time constant of left ventricular relaxation (Tc) were lowered in cell infusion groups (all P<0.01). There were no significant differences in cardiac function indexes between intravenous infusion and trans-epicardial injection group (all P>0.05)
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|a CONCLUSION: Intravenous and trans-epicardial delivery of hematopoietic stem cells (HSC) can significantly improve cardiac function, and both methods may be safe and effective for the treatment of AMI
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|a English Abstract
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Antigens, CD34
|2 NLM
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| 700 |
1 |
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|a Li, Wei-min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Cui-ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jing, Ling
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 20(2008), 4 vom: 18. Apr., Seite 214-7
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:20
|g year:2008
|g number:4
|g day:18
|g month:04
|g pages:214-7
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