Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease

Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease

To identify factors related to progression to CMV end-organ disease, cytokine production, proliferative capacity and phenotype of CMV-specific CD4(+) T-cells were analysed longitudinally. Numbers of IFNgamma(+)CD4(+) and IFNgamma(+)IL-2(+)CD4(+) T-cells tended to decrease in individuals progressing...

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Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 2 vom: 15. Aug., Seite 190-9
Auteur principal: Bronke, Corine (Auteur)
Autres auteurs: Jansen, Christine A, Westerlaken, Geertje H A, De Cuyper, Iris M, Miedema, Frank, Tesselaar, Kiki, van Baarle, Debbie
Format: Article
Langue:English
Publié: 2007
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Interleukin-2 Tumor Necrosis Factor Receptor Superfamily, Member 7 Interferon-gamma 82115-62-6 Leukocyte Common Antigens EC 3.1.3.48