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01000naa a22002652 4500 |
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NLM170499391 |
| 003 |
DE-627 |
| 005 |
20231223123633.0 |
| 007 |
tu |
| 008 |
231223s2007 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0568.xml
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| 035 |
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|a (DE-627)NLM170499391
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| 035 |
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|a (NLM)17524809
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Koczwara, Kerstin
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 10.08.2007
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| 500 |
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|a Date Revised 17.11.2011
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Insulin autoantibodies (IAA) precede clinical type 1 diabetes in children. Immunization events leading to IAA are unknown. The aim of this study was to determine whether some IAA result from mucosal immunization. IgA-IAA and binding of IAA to non-human insulin were examined in selected high and low affinity IAA-positive samples and in first IAA-positive samples from children aged <2 years. High affinity IAA (>10(9)L/mol) bound strongly to human insulin and poorly to chicken insulin. In contrast, 12/13 lower affinity IAA were chicken insulin-reactive, binding equally to human and chicken insulin (n=4), or preferentially binding chicken insulin (n=8). IgA-IAA were found in association with chicken insulin-reactive IAA, and included cases where IgA-IAA predominated over IgG-IAA. Among 20 IAA-positive children aged <2 years, one had early IgA-chicken insulin-reactive IAA that were replaced by high affinity IgG-IAA. The findings suggest that some IAA can result from immunization against molecules other than human insulin at mucosal sites
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin A
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Insulin
|2 NLM
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| 650 |
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7 |
|a Insulin Antibodies
|2 NLM
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| 700 |
1 |
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|a Muller, Daniela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Achenbach, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ziegler, Anette-G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bonifacio, Ezio
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 124(2007), 1 vom: 15. Juli, Seite 77-82
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:124
|g year:2007
|g number:1
|g day:15
|g month:07
|g pages:77-82
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 124
|j 2007
|e 1
|b 15
|c 07
|h 77-82
|