Potent antitumor activity of a tumor-specific soluble TCR/IL-2 fusion protein

Potent antitumor activity of a tumor-specific soluble TCR/IL-2 fusion protein

We previously have generated a single-chain T cell receptor-cytokine fusion protein (264scTCR/IL-2) comprising interleukin-2 genetically linked to a soluble HLA-A2.1-restricted TCR recognizing a peptide of human p53 protein. In this report, we show that 264scTCR/IL-2 inhibits the growth of primary t...

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Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 121(2006), 1 vom: 19. Okt., Seite 29-39
Auteur principal: Belmont, Heather J (Auteur)
Autres auteurs: Price-Schiavi, Shari, Liu, Bai, Card, Kimberlyn F, Lee, Hyung-Il, Han, Kai-Ping, Wen, Jinghai, Tang, Shamay, Zhu, Xiaoyung, Merrill, Jane, Chavillaz, Pierre-Andre, Wong, Jeffrey L, Rhode, Peter R, Wong, Hing C
Format: Article
Langue:English
Publié: 2006
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Comparative Study Journal Article Research Support, N.I.H., Extramural Antineoplastic Agents Interleukin-2 Receptors, Antigen, T-Cell Recombinant Fusion Proteins Tumor Suppressor Protein p53