T cell repertoire and Epstein-Barr virus-specific T cell response in chronic active Epstein-Barr virus infection a case study

T cell repertoire and Epstein-Barr virus-specific T cell response in chronic active Epstein-Barr virus infection : a case study

In a patient with chronic active Epstein-Barr virus infection associated with vasculitis and fulminant CD4+ T cell lymphoproliferative disorder, we probed the peripheral blood mononuclear cells (PBMC) for the presence of an EBV-specific T cell repertoire and tested the possible relationship between...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 119(2006), 1 vom: 15. Apr., Seite 79-86
1. Verfasser: Gallot, Géraldine (VerfasserIn)
Weitere Verfasser: Hamidou, Mohamed A, Clémenceau, Béatrice, Gaschet, Joëlle, Tiberghien, Pierre, Ferrand, Christophe, Vivien, Régine, Barbarot, Sébastien, Coste-Burel, Marianne, Moreau, Anne, Vié, Henri
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Case Reports Journal Article Research Support, Non-U.S. Gov't Complementarity Determining Regions DNA, Viral Epitopes, T-Lymphocyte Peptide Fragments Receptors, Antigen, T-Cell, alpha-beta Tumor Necrosis Factor-alpha Viral Proteins
Beschreibung
Zusammenfassung:In a patient with chronic active Epstein-Barr virus infection associated with vasculitis and fulminant CD4+ T cell lymphoproliferative disorder, we probed the peripheral blood mononuclear cells (PBMC) for the presence of an EBV-specific T cell repertoire and tested the possible relationship between the lymphocytic infiltrate and the EBV-specific T cell response. Our results give credence to the presence of an apparently normal EBV-specific memory T cell response after in vitro reactivation of the patient's PBMC with autologous infected B lymphoblastoid cell lines. In keeping with the characterization of the vasculitis, certain T cell subsets were detected after expansion of skin lesion-infiltrating lymphocytes and were found to be infected with EBV. These particular T cell expansions were neither the effectors nor the targets of the in vitro reactivated EBV-specific T cells, thus excluding a simple relationship between EBV, the skin lesions, and the T cell expansions frequently observed in these patients
Beschreibung:Date Completed 17.04.2006
Date Revised 10.12.2019
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-6616