Preparation of a highly stable niosome and its hydrotrope-solubilization action to drugs
Highly stable niosomes are prepared and investigated in Tween80/PEG6000/Span80/H2O system. The mean radius of the niosomes is 0.15-0.2 microm. The contents of PEG6000 and Span80 and the system temperature affect the size and the stability of the niosome. A certain Span80 can remarkably improve the s...
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 21(2005), 24 vom: 22. Nov., Seite 11034-9 |
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| Format: | Article |
| Langue: | English |
| Publié: |
2005
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids |
| Sujets: | Journal Article Drug Carriers Hexoses Liposomes Pharmaceutical Preparations Polysorbates sorbitan monooleate 06XEA2VD56 Polyethylene Glycols 3WJQ0SDW1A |
| Résumé: | Highly stable niosomes are prepared and investigated in Tween80/PEG6000/Span80/H2O system. The mean radius of the niosomes is 0.15-0.2 microm. The contents of PEG6000 and Span80 and the system temperature affect the size and the stability of the niosome. A certain Span80 can remarkably improve the stability. The niosome is provided distinctly with the hydrotrope-solubilization action to the hydrophilic drug and hydrophobic drug, which affects the niosome membrane. The mechanism of the effects of PEG6000 and Span80 on the niosome is discussed in this paper |
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| Description: | Date Completed 05.04.2007 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
| ISSN: | 1520-5827 |