Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease

Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease

Tumor necrosis factor (TNF)-alpha plays a critical role in the initiation and progression of Crohn's disease, a chronic inflammatory disorder of the gastrointestinal tract. Infliximab, a chimeric monoclonal antibody blocking TNF-alpha, has proven effective as an induction and maintenance therap...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 1 vom: 03. Jan., Seite 11-9
1. Verfasser: Candon, Sophie (VerfasserIn)
Weitere Verfasser: Mosca, Alexis, Ruemmele, Frank, Goulet, Olivier, Chatenoud, Lucienne, Cézard, Jean-Pierre
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibodies, Anti-Idiotypic Antibodies, Blocking Antibodies, Monoclonal Tumor Necrosis Factor-alpha Infliximab B72HH48FLU