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NLM156774674 |
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231223s2005 xx ||||| 00| ||eng c |
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|a pubmed25n0523.xml
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|a (DE-627)NLM156774674
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|a (NLM)16042429
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lafitte, Géraldine
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Mixtures of mucin and oppositely charged surfactant aggregates with varying charge density. Phase behavior, association, and dynamics
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| 264 |
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|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.06.2006
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|a Date Revised 01.12.2018
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|a published: Print
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|a Citation Status MEDLINE
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|a The nonionic surfactant Tween80 is a commonly used excipient in drug formulations containing an active substance with low aqueous solubility. Model drug vehicles with varying charge density were obtained by mixing Tween80 (PS-80) with the cationic surfactant Tetradecyltrimethylammonium chloride (TTAC), thus forming mixed micelles. The micelles were mixed with the negatively charged polyelectrolyte mucin, which is a component in the protective mucus layer covering epithelial cell linings. Depending on the composition of the mixture, complex-formation could be followed by precipitation. Using X-ray diffraction, it was found that the precipitate contained a lamellar phase with properties sensitive to the proportion of PS-80. Higher amounts of PS-80 were found to oppose phase separation. Further analysis in the one-phase region, or alternatively of the supernatant of two-phase samples, by (1)H NMR, HPLC, and diffusion measurements with PGSE-NMR led to the conclusions that at low proportion of PS-80 aggregates composed of mixed (PS-80 and TTAC) micelles and mucin were formed, whereas increased concentrations of PS-80 favored the dissolution of the precipitate and limited the interactions between mixed micelles and the polymer
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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7 |
|a Cations
|2 NLM
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7 |
|a Micelles
|2 NLM
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| 650 |
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7 |
|a Mucins
|2 NLM
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7 |
|a Polymers
|2 NLM
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| 650 |
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|a Polysorbates
|2 NLM
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|a Quaternary Ammonium Compounds
|2 NLM
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|a Surface-Active Agents
|2 NLM
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| 650 |
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|a Trimethyl Ammonium Compounds
|2 NLM
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| 650 |
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7 |
|a tetradecyltrimethylammonium
|2 NLM
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| 650 |
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7 |
|a Y3IR7RCT6J
|2 NLM
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| 700 |
1 |
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|a Thuresson, Krister
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Söderman, Olle
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 21(2005), 16 vom: 02. Aug., Seite 7097-104
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
8 |
|g volume:21
|g year:2005
|g number:16
|g day:02
|g month:08
|g pages:7097-104
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|d 21
|j 2005
|e 16
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|h 7097-104
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