Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS

Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS

DNA methylation abnormalities have recently emerged as one of the most frequent molecular changes in hematopoietic neoplasms. Since methylation and transcriptional status are inversely correlated, the hypermethylation of genes involved in cell-cycle control and apoptosis could have a pathogenetic ro...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 109(2003), 1 vom: 30. Okt., Seite 89-102
1. Verfasser: Leone, Giuseppe (VerfasserIn)
Weitere Verfasser: Voso, Maria Teresa, Teofili, Luciana, Lübbert, Michael
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Review Histones Cytidine 5CSZ8459RP Decitabine 776B62CQ27 Azacitidine M801H13NRU