Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice

Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice

IL-10 is an important regulatory cytokine in the mucosal immune system, as supported by the fact that mice deficient in IL-10 spontaneously develop Crohn's disease-like colitis. An aberrant, Th1-driven CD4(+) T-cell response to enteric bacteria seems to be important in the pathogenesis of this...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 102(2002), 3 vom: 22. März, Seite 237-48
1. Verfasser: Takahashi, Ichiro (VerfasserIn)
Weitere Verfasser: Matsuda, Jennifer, Gapin, Laurent, DeWinter, Hilde, Kai, Yasuyuki, Tamagawa, Hiroshi, Kronenberg, Mitchell, Kiyono, Hiroshi
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Interleukin-10 130068-27-8