Human antimicrobial peptides : analysis and application
Antimicrobial peptides are innate host defense molecules that have a direct effect on bacteria, fungi and enveloped viruses. They are found in evolutionarily diverse species ranging from prokaryotes and plants to invertebrate and vertebrate animals. Humans express several families of antimicrobial p...
| Publié dans: | BioTechniques. - 1991. - 29(2000), 4 vom: 06. Okt., Seite 822-6, 828, 830-1 |
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| Format: | Article |
| Langue: | English |
| Publié: |
2000
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| Accès à la collection: | BioTechniques |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review Anti-Bacterial Agents Antimicrobial Cationic Peptides Cathelicidins alpha-Defensins beta-Defensins |
| Résumé: | Antimicrobial peptides are innate host defense molecules that have a direct effect on bacteria, fungi and enveloped viruses. They are found in evolutionarily diverse species ranging from prokaryotes and plants to invertebrate and vertebrate animals. Humans express several families of antimicrobial peptides in myeloid cells and on various epithelial surfaces where they are poised to defend against pathogens. Recently, antimicrobial peptides from animals and plants have served as templates for the design of new therapeutic antibiotics. This review provides an introduction to the biology of human antimicrobial peptides, followed by a more detailed discussion of their isolation from tissues and biological fluids, their purification by gel electrophoresis and chromatography and assays of their antimicrobial activities |
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| Description: | Date Completed 08.02.2001 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
| ISSN: | 1940-9818 |