Pharmacokinetics of high-dose cisplatin administration (relationship between pharmacokinetics and administration schedule)
Three cases of urogenital malignancy were treated with 80-120/m2 of cisplatin by a 0.5-hour (rapid) or 4-hour (slow) infusion. Each patient received three courses of repeated chemotherapy. The kinetics of total platinum was measured up to 48 hours in the blood and urine. The blood peak concentration...
| Publié dans: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 33(1987), 11 vom: 15. Nov., Seite 1760-5 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , , , |
| Format: | Article |
| Langue: | Japanese |
| Publié: |
1987
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| Accès à la collection: | Hinyokika kiyo. Acta urologica Japonica |
| Sujets: | Case Reports English Abstract Journal Article Cisplatin Q20Q21Q62J |
| Résumé: | Three cases of urogenital malignancy were treated with 80-120/m2 of cisplatin by a 0.5-hour (rapid) or 4-hour (slow) infusion. Each patient received three courses of repeated chemotherapy. The kinetics of total platinum was measured up to 48 hours in the blood and urine. The blood peak concentrations were achieved 6.0 micrograms/ml by rapid infusion, 2.0 micrograms/ml by slow infusion. The time dependent urinary excretion rate against total administered dose was 40% in 60 min. by rapid infusion, 20% in 16 hours by slow infusion. The volume of distribution correlated with infusion time. Rapid infusion way of cisplatin could be better to treat the patient with bulky tumor mass or patients with uroepithelial cancer like CIS, because a higher blood and urine concentration can be obtained than by slow infusion |
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| Description: | Date Completed 25.04.1988 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |