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|a (DE-627)JST040724298
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|a (JST)4485770
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a LeBlanc, Gerald A.
|e verfasserin
|4 aut
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|a Testosterone-Fatty Acid Esterification: A Unique Target for the Endocrine Toxicity of Tributyltin to Gastropods
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|c 2005
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
|b c
|2 rdamedia
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|a Online-Ressource
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|a Over the past thirty years, a global occurrence of sexual aberration has occurred whereby females among populations of prosobranch snails exhibit male sex characteristics. This condition, called imposex, has been causally associated with exposure to the biocide tributyltin. Tributyltin-exposed, imposex snails typically have elevated levels of testosterone which have led to the postulate that this endocrine dysfunction is responsible for imposex. This overview describes recent evidence that supports this postulate. Gastropods maintain circulating testosterone levels and administration of testosterone to females or castrates stimulates male sex differentiation in several snail species. Studies in the mud snail (Ilyanassa obsoleta) have shown that gastropods utilize a unique strategy for regulating free testosterone levels. Excess testosterone is converted to fatty acid esters by the action of a testosterone-inducible, high capacity/low affinity enzyme, acyl-CoA:testosterone acyl transferase, and stored within the organisms. Free testosterone levels are regulated during the reproductive cycle apparently due to changes in esterification/desterification suggesting that testosterone functions in the reproductive cycle of the organisms. Testosterone esterification provides a unique target in the testosterone regulatory machinery of snails that is altered by tributyltin. Indeed, imposex and free testosterone levels were elevated in field collected snails containing high tin levels, while testosterone-fatty acid ester pools were reduced in these organisms. These observations indicate that tributyltin elevates free testosterone by reducing the retention of testosterone as fatty acid-esters. This endocrine effect of tributyltin may be responsible for imposex.
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|a Copyright 2005 Society for Integrative and Comparative Biology
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|a Biological sciences
|x Biochemistry
|x Biomolecules
|x Hormones
|x Steroid hormones
|x Sex hormones
|x Androgens
|x Testosterone
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650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mollusks
|x Snails
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650 |
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4 |
|a Physical sciences
|x Earth sciences
|x Geology
|x Petrology
|x Sedimentary petrology
|x Sediments
|x Mud
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650 |
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4 |
|a Physical sciences
|x Chemistry
|x Chemical compounds
|x Chemicals
|x Acids
|x Carboxylic acids
|x Fatty acids
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650 |
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4 |
|a Physical sciences
|x Chemistry
|x Chemical compounds
|x Chemicals
|x Acids
|x Carboxylic acids
|x Esters
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650 |
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4 |
|a Biological sciences
|x Biology
|x Anatomy
|x Reproductive system
|x Genitalia
|x Male genitalia
|x Penis
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650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mollusks
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650 |
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4 |
|a Biological sciences
|x Biology
|x Developmental biology
|x Reproduction
|x Sex
|x Sex characteristics
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650 |
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4 |
|a Behavioral sciences
|x Ethology
|x Animal behavior
|x Animal social behavior
|x Mating behavior
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650 |
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4 |
|a Physical sciences
|x Chemistry
|x Chemical compounds
|x Chemicals
|x Polymers
|x Biopolymers
|x Proteins
|x Enzymes
|x Endocrinology and Immunology of Invertebrate Phyla
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|a research-article
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700 |
1 |
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|a Gooding, Meredith P.
|e verfasserin
|4 aut
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773 |
0 |
8 |
|i Enthalten in
|t Integrative and Comparative Biology
|d Society for Integrative and Comparative Biology
|g 45(2005), 1, Seite 81-87
|w (DE-627)393388077
|w (DE-600)2159110-6
|x 15577023
|7 nnns
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773 |
1 |
8 |
|g volume:45
|g year:2005
|g number:1
|g pages:81-87
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|u https://www.jstor.org/stable/4485770
|3 Volltext
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|d 45
|j 2005
|e 1
|h 81-87
|