Anoctamins CTMD method Journal Article Membrane Lipids Phospholipid Transfer Proteins Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. cryo-EM structure determination functional mechanisms of TMEM16 scramblases lipid nanodiscs lipid-dependent gating of TMEM16 scramblases membrane remodeling molecular dynamics (MD) simulation phospholipid scramblases protein-membrane interactions time-structure Independent Component Analysis (tICA)