Journal Article Research Support, Non-U.S. Gov't 059QF0KO0R 0U46U6E8UK 2G12 monoclonal antibody ADP-ribosyl Cyclase 1 Antibodies, Monoclonal Antibodies, Neutralizing Broadly Neutralizing Antibodies EC 3.2.2.6 Gangliosides HIV Antibodies HIV-1 Mannose Monosaccharides NAD PHA4727WTP Polysaccharides Sialic Acids Viral Proteins Water a large scale quantum mechanical calculation binding free energy glycan-antibody interaction high mannose glycan human immunodeficiency virus type-1 molecular dynamics neutralizing antibody saccharide water molecules