Journal Article Research Support, Non-U.S. Gov't X-ray free-electron laser serial femtosecond crystallography SACLA XFEL 059QF0KO0R 7440-57-5 A2A adenosine receptor Bragg coherent diffraction imaging CITIUS EC 3.2.1.17 Gold K computer Ligands Muramidase Water X-ray imaging archaerhodopsin-3 arrival-timing monitor beamline instrumentation big-data analysis charge-integrating detectors classification of diffraction patterns coherent X-ray diffraction imaging data analysis double-multilayer monochromator dynamic range fourth-generation synchrotrons free-electron laser